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ISRCTN
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ISRCTN43055332
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DOI
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10.1186/ISRCTN43055332
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ClinicalTrials.gov identifier
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EudraCT number
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Public title
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CANcer DIagnosis Decision rules
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Scientific title
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CANcer DIagnosis Decision rules: an observational study
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Acronym
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CANDID
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Serial number at source
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13492
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Study hypothesis
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This study seeks to work out which of the symptoms and examination findings are the most effective in the early prediction of lung or colon cancer.
We aim to recruit up to 20,000 patients who consult their GP half with lung symptoms and the other half with colorectal symptoms. Clinical information will be collected using standardised internet based forms.
The clinical prediction 'rules' or decision aids developed from these studies will then be tested, with 2000 patients for each condition, for validity.
More details can be found at: http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=13492
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Lay summary
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Lay summary under review with external organisation
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Ethics approval
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Ethics Committee is South Central Oxford A, First MREC approval date 31/07/2012, ref: 12/SC/0328
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Study design
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Non-randomised observational cohort study
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Cancer / Primary care study
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Participants - inclusion criteria
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Male and female over 35 with lung or colorectal symptoms
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Participants - exclusion criteria
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1. Already has a diagnosis of cancer
2. Unable to give informed consent
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Anticipated start date
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31/01/2013
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Anticipated end date
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31/01/2016
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Status of trial
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Ongoing |
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Patient information material
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Not available in web format, please use the contact details below to request a patient information sheet
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Target number of participants
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UK Sample Size: 20000
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Interventions
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Willing patients will complete lifestyle questionnaires and provide blood or saliva samples (including for genetic analysis). A notes review will also be undertaken. The National Cancer and Mortality Registries will then be monitored to see which patients develop cancer, and statistical analysis will determine the most important clinical variables that predict cancer.
Follow Up Length: 60 month(s)
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Primary outcome measure(s)
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Participant appearing in cancer or mortality registries; Timepoint(s): up to 5 years post recruitment
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Secondary outcome measure(s)
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No secondary outcome measures
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Sources of funding
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National School for Primary Care Research (UK)
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Trial website
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Publications
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Contact name
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Mrs
Susan
Broomfield
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Address
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Primary Medical Care
Aldermoor Health Centre
Aldermoor Close
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City/town
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Southampton
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Zip/Postcode
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SO16 5ST
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Country
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United Kingdom
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Email
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seb4@soton.ac.uk
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Sponsor
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University of Southampton (UK)
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Address
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Research Governance Office
George Thomas Building 37
Room 4055
Highfield
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City/town
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Southampton
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Zip/Postcode
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SO17 1BJ
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Country
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United Kingdom
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Sponsor website:
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http://www.southampton.ac.uk
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Date applied
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12/12/2012
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Last edited
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14/03/2013
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Date ISRCTN assigned
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12/03/2013
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