Condition category
Mental and Behavioural Disorders
Date applied
Date assigned
Last edited
Prospectively registered
Overall trial status
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information



Primary contact

Dr Paula Goering


Contact details

33 Russell Street
M5S 2S1
+1 (0)416 979 6844

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

Multi-site pragmatic randomised controlled field trial of Housing First versus treatment as usual in mental health and homelessness


Study hypothesis

What is the effectiveness, cost/benefit, and cost/effectiveness of Housing First in comparison to care as usual for homeless adults?

Ethics approval

Pending as of 08/06/2009 from the Centre for Addiction and Mental Health Research Ethics Board (CAMH REB); expected in Autumn 2009 after each of five primary data collection sites have obtained ethics approval.

Study design

Multi-method multi-site unblinded randomised controlled field trial

Primary study design


Secondary study design

Randomised controlled trial

Trial setting


Trial type


Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet


Homelessness and serious mental illness


Treatment: provision of rent supplements and case management or assertive community treatment for the duration of the study
Comparison: care as usual

Duration of intervention: Data collection will be ongoing from Sept 2009 to Feb 2013 with duration of intervention from 24 to 42 months.
Duration of follow-up: two years

Intervention type



Not Applicable

Drug names

Primary outcome measures

Housing Stability: Tsemberis Residential Timeline Follow-back Inventory, measured at 6, 12, 18 and 24 months.

Secondary outcome measures

Quality of Life: EQ-5D, measured at 6, 12, 18 and 24 months.

Overall trial start date


Overall trial end date


Reason abandoned


Participant inclusion criteria

1. Legal adult status
2. Absolute homelessness or precariously housed
3. Presence of a serious mental disorder
4. Aged 18 years and older, either sex

Participant type


Age group




Target number of participants


Participant exclusion criteria

Does not meet inclusion criteria

Recruitment start date


Recruitment end date



Countries of recruitment


Trial participating centre

Centre for Addiction and Mental Health
Toronto, Ontario
M5S 2S1

Sponsor information


Mental Health Commission of Canada (Canada)

Sponsor details

c/o Jayne Barker
10301 Southport Lane SW
T2W 1S7

Sponsor type




Funder type


Funder name

Health Canada (Canada)

Alternative name(s)

Santé Canada

Funding Body Type

government organisation

Funding Body Subtype

Federal/National Government



Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2011 protocol in:
2012 results in:
2012 childhood learning disability results in:
2014 cumulative childhood adversity results in:
2014 discrimination results in:
2014 results in:
2015 results in:
2015 results in:
2015 results in:
2015 results in:
2015 results in:

Publication citations

  1. Results

    Stergiopoulos V, O'Campo P, Gozdzik A, Jeyaratnam J, Corneau S, Sarang A, Hwang SW, Moving from rhetoric to reality: adapting Housing First for homeless individuals with mental illness from ethno-racial groups., BMC Health Serv Res, 2012, 12, 345, doi: 10.1186/1472-6963-12-345.

  2. Childhood learning disability results

    Patterson ML, Moniruzzaman A, Frankish CJ, Somers JM, Missed opportunities: childhood learning disabilities as early indicators of risk among homeless adults with mental illness in Vancouver, British Columbia., BMJ Open, 2012, 2, 6, doi: 10.1136/bmjopen-2012-001586.

  3. Cumulative childhood adversity results

    Patterson ML, Moniruzzaman A, Somers JM, Setting the stage for chronic health problems: cumulative childhood adversity among homeless adults with mental illness in Vancouver, British Columbia., BMC Public Health, 2014, 14, 350, doi: 10.1186/1471-2458-14-350.

  4. Discrimination results

    Skosireva A, O Campo P, Zerger S, Chambers C, Gapka S, Stergiopoulos V, Different faces of discrimination: perceived discrimination among homeless adults with mental illness in healthcare settings., BMC Health Serv Res, 2014, 14, 1, 376, doi: 10.1186/1472-6963-14-376.

  5. Results

    Stergiopoulos V, Gozdzik A, O'Campo P, Holtby AR, Jeyaratnam J, Tsemberis S, Housing First: exploring participants' early support needs, BMC Health Serv Res, 2014 , 14, 167, doi: 10.1186/1472-6963-14-167.

  6. Results

    Stergiopoulos V, Hwang SW, Gozdzik A, Nisenbaum R, Latimer E, Rabouin D, Adair CE, Bourque J, Connelly J, Frankish J, Katz LY, Mason K, Misir V, O'Brien K, Sareen J, Schütz CG, Singer A, Streiner DL, Vasiliadis HM, Goering PN; for the At Home/Chez Soi Investigators, Effect of Scattered-Site Housing Using Rent Supplements and Intensive Case Management on Housing Stability Among Homeless Adults With Mental Illness: A Randomized Trial, JAMA, 2015, 313, 9, 905-915, doi: 10.1001/jama.2015.1163.

  7. Results

    Goering PN, Streiner DL, Adair C, Aubry T, Barker J, Distasio J, Hwang SW, Komaroff J, Latimer E, Somers J, Zabkiewicz DM, The At Home/Chez Soi trial protocol: a pragmatic, multi-site, randomised controlled trial of a Housing First intervention for homeless individuals with mental illness in five Canadian cities, BMJ Open, 2011, 1, 2, e000323, doi: 10.1136/bmjopen-2011-000323.

  8. Results

    Kirst M, Zerger S, Misir V, Hwang S, Stergiopoulos V, The impact of a Housing First randomized controlled trial on substance use problems among homeless individuals with mental illness, Drug Alcohol Depend, 2015 , 146, 24-29, doi: 10.1016/j.drugalcdep.2014.

  9. Results

    Zerger S, Bacon S, Corneau S, Skosireva A, McKenzie K, Gapka S, O'Campo P, Sarang A, Stergiopoulos V, Differential experiences of discrimination among ethnoracially diverse persons experiencing mental illness and homelessness, BMC Psychiatry, 2014 , 14, 1, 353, doi: 10.1186/s12888-014-0353-1.

  10. Results

    Gozdzik A, Salehi R, O'Campo P, Stergiopoulos V, Hwang SW, Cardiovascular risk factors and 30-year cardiovascular risk in homeless adults with mental illness, BMC Public Health, 2015 , 15, 165, doi: 10.1186/s12889-015-1472-4.

  11. Results

    Stergiopoulos V, Gozdzik A, Misir V, Skosireva A, Connelly J, Sarang A, Whisler A, Hwang SW, O'Campo P, McKenzie K, Effectiveness of Housing First with Intensive Case Management in an Ethnically Diverse Sample of Homeless Adults with Mental Illness: A Randomized Controlled Trial, PLoS One, 2015 , 10, 7, e0130281, doi: 10.1371/journal.pone.0130281.

Additional files

Editorial Notes