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ISRCTN
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ISRCTN39345394
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ClinicalTrials.gov identifier
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Public title
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A randomised controlled multi-centre treatment trial of adolescent anorexia nervosa, including assessment of cost effectiveness and patient acceptability
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Scientific title
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Acronym
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TOUCAN
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Serial number at source
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HTA 97/42/02
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Study hypothesis
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To evaluate, by means of a randomised controlled trial, the cost effectiveness of inpatient against outpatient treatment of adolescent anorexia nervosa and general against specialist treatment, with the following hypotheses:
1. There will be no difference in clinical outcome between inpatient and outpatient treatment in the medium and long term (1 and 2 years) by intention to treat.
2. Specialist outpatient treatment will be more clinically and cost effective than general outpatient treatment.
3. Outpatient treatment will be more cost effective than inpatient treatment.
4. Outpatient treatment will be more acceptable to subject and family in terms of general satisfaction and quality of life.
Please note that, as of 15/01/2008, the anticipated end date of this trial has been updated from 30/06/2004 to 31/12/2008.
Please note that, as of 28/0/2009, the anticipated end date of this trial has been updated from 31/12/2008 to 30/06/2009.
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Lay summary
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Ethics approval
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Does not match inclusion criteria
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Anorexia nervosa
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Participants - inclusion criteria
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1. All new cases of (Diagnostic and Statistical Manual of Mental Disorders, Fourth edition [DSM IV]) anorexia nervosa
2. Aged 12 - 18 years inclusive
3. Presenting to Child and Adolescent Mental Health Services (CAMHS), Regional Adolescent Services, or Specialist Eating Disorder Services in the North West Region over a two year period
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Participants - exclusion criteria
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Not provided at time of registration.
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Anticipated start date
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01/01/2000
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Anticipated end date
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30/06/2009
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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167
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Interventions
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1. Routine outpatient treatment by CAMHS
2. Specialist outpatient treatment package (12 sessions) as used in existing Chester service
3. Inpatient treatment.
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Primary outcome measure(s)
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Composite clinical measure of physical, social and psychological outcome based on Morgan and Russell Scales (MRAOS).
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Secondary outcome measure(s)
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1. Percentage weight for height
2. Family functioning
3. Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA)
4. Patient and family acceptablity
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Sources of funding
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NIHR Health Technology Assessment Programme - HTA (UK)
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Trial website
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Publications
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1. 2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17978323
2. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20334748
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Contact name
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Prof
Simon
Gowers
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Address
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Department of Psychiatry
University of Liverpool
Academic Unit
Pine Lodge
79 Liverpool Road
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City/town
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Chester
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Zip/Postcode
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CH2 1AW
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Country
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United Kingdom
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Tel
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+44 (0)1244 364660
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Fax
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+44 (0)1244 364659
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Email
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s.gowers@liv.ac.uk
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Sponsor
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University of Liverpool (UK)
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Address
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Research Support Office
The Foresight Building
3 Brownlow Street
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City/town
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Liverpool
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Zip/Postcode
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L69 3GL
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Country
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United Kingdom
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Email
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Sponsor website:
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http://www.liv.ac.uk/
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Date applied
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25/04/2003
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Last edited
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16/08/2010
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Date ISRCTN assigned
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25/04/2003
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