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A randomised controlled multi-centre treatment trial of adolescent anorexia nervosa, including assessment of cost effectiveness and patient acceptability
ISRCTN ISRCTN39345394
DOI 10.1186/ISRCTN39345394
ClinicalTrials.gov identifier
EudraCT number
Public title A randomised controlled multi-centre treatment trial of adolescent anorexia nervosa, including assessment of cost effectiveness and patient acceptability
Scientific title
Acronym TOUCAN
Serial number at source HTA 97/42/02
Study hypothesis To evaluate, by means of a randomised controlled trial, the cost effectiveness of inpatient against outpatient treatment of adolescent anorexia nervosa and general against specialist treatment, with the following hypotheses:
1. There will be no difference in clinical outcome between inpatient and outpatient treatment in the medium and long term (1 and 2 years) by intention to treat.
2. Specialist outpatient treatment will be more clinically and cost effective than general outpatient treatment.
3. Outpatient treatment will be more cost effective than inpatient treatment.
4. Outpatient treatment will be more acceptable to subject and family in terms of general satisfaction and quality of life.

Please note that, as of 15/01/2008, the anticipated end date of this trial has been updated from 30/06/2004 to 31/12/2008.

Please note that, as of 28/0/2009, the anticipated end date of this trial has been updated from 31/12/2008 to 30/06/2009.
Lay summary
Ethics approval Does not match inclusion criteria
Study design Randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Anorexia nervosa
Participants - inclusion criteria 1. All new cases of (Diagnostic and Statistical Manual of Mental Disorders, Fourth edition [DSM IV]) anorexia nervosa
2. Aged 12 - 18 years inclusive
3. Presenting to Child and Adolescent Mental Health Services (CAMHS), Regional Adolescent Services, or Specialist Eating Disorder Services in the North West Region over a two year period
Participants - exclusion criteria Not provided at time of registration.
Anticipated start date 01/01/2000
Anticipated end date 30/06/2009
Status of trial Completed
Patient information material
Target number of participants 167
Interventions 1. Routine outpatient treatment by CAMHS
2. Specialist outpatient treatment package (12 sessions) as used in existing Chester service
3. Inpatient treatment.
Primary outcome measure(s) Composite clinical measure of physical, social and psychological outcome based on Morgan and Russell Scales (MRAOS).
Secondary outcome measure(s) 1. Percentage weight for height
2. Family functioning
3. Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA)
4. Patient and family acceptablity
Sources of funding NIHR Health Technology Assessment Programme - HTA (UK)
Trial website
Publications 1. 2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17978323
2. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20334748
Contact name Prof  Simon  Gowers
  Address Department of Psychiatry
University of Liverpool
Academic Unit
Pine Lodge
79 Liverpool Road
  City/town Chester
  Zip/Postcode CH2 1AW
  Country United Kingdom
  Tel +44 (0)1244 364660
  Fax +44 (0)1244 364659
  Email s.gowers@liv.ac.uk
Sponsor University of Liverpool (UK)
  Address Research Support Office
The Foresight Building
3 Brownlow Street
  City/town Liverpool
  Zip/Postcode L69 3GL
  Country United Kingdom
  Email
  Sponsor website: http://www.liv.ac.uk/
Date applied 25/04/2003
Last edited 16/08/2010
Date ISRCTN assigned 25/04/2003
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