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ISRCTN
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ISRCTN35444083
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ClinicalTrials.gov identifier
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Public title
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Pharmacogenomics of opioids: an investigation of the genetic determinants of variability in analgesic response to opioids.
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Scientific title
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Acronym
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N/A
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Serial number at source
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N0258123628
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Study hypothesis
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The primary aim of this research project is to test the hypothesis that inter-subject variability in response to morphine is determined by polymorphisms in the u-opioid receptor gene.
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Not Applicable:
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Participants - inclusion criteria
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Total number RMH patients 100
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Participants - exclusion criteria
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Not provided at time of registration
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Anticipated start date
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01/10/2003
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Anticipated end date
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01/10/2005
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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100
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Interventions
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Randomised, blinded (Phase 2).
Each subject will act as their own control. On visit one, subjects will be randomised to receive either intravenous morphine or intravenous saline (placebo). They will then cross-over to receive placebo or morphine respectively at the second visit.
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Primary outcome measure(s)
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Not provided at time of registration
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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The Royal Marsden NHS Trust
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Trial website
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Publications
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Contact name
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Dr
Julia
Riley
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Address
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Palliative Care
Royal Marsden NHS Trust
Fulham Road
Chelsea
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City/town
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London
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Zip/Postcode
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SW3 6JJ
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Country
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United Kingdom
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Tel
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+44 (0)20 7352 8171
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Fax
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+44 (0)20 7808 2048
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Email
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Julia.Riley@rmh.nhs.uk
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Sponsor
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Record Provided by the NHSTCT Register - 2004 Update - Department of Health (UK)
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Address
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The Department of Health,
Richmond House,
79 Whitehall
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City/town
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London
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Zip/Postcode
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SW1A 2NL
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Country
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United Kingdom
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Tel
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+44 (0)20 7307 2622
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Email
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dhmail@doh.gsi.org.uk
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Sponsor website:
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http://www.dh.gov.uk/Home/fs/en
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Date applied
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30/09/2004
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Last edited
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02/12/2010
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Date ISRCTN assigned
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30/09/2004
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