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Selective Digestive Decontamination (SDD) - Selective Orophayngeal Decontamination (SOD) trial
ISRCTN ISRCTN35176830
DOI 10.1186/ISRCTN35176830
ClinicalTrials.gov identifier
EudraCT number
Public title Selective Digestive Decontamination (SDD) - Selective Orophayngeal Decontamination (SOD) trial
Scientific title
Acronym SDD-SOD-trial
Serial number at source N/A
Study hypothesis Can mortality in intensive care unit (ICU) patients be reduced by using SDD or SOD as infection prevention measure, without increasing the development of antibiotic resistance?
Lay summary
Ethics approval Not provided at time of registration
Study design Randomised controlled trial
Countries of recruitment Netherlands
Disease/condition/study domain Infection in ICU patients
Participants - inclusion criteria All patients admitted to the ICU with an expected stay> 72 hours in ICU or with an expected duration of mechanical ventilation > 48 hours
Participants - exclusion criteria 1. Known allergy to study-medication in patient-history
2. Pregnancy
Anticipated start date 01/05/2004
Anticipated end date 24/07/2006
Status of trial Completed
Patient information material
Target number of participants 3,450
Interventions Selective Digestive Decontamination.
Selective Oropharyngeal Decontamination.
Primary outcome measure(s) 1. Hospital mortality
2. ICU-mortality
Secondary outcome measure(s) 1. Prevalence of antibiotic resistance
2. Duration of mechanical ventilation,
3. Duration of ICU-stay,
4. Incidence of hospital infections,
5. Antibiotic use,
6. Health care costs.
Sources of funding Dutch SDD Trialists Group (Netherlands)
Trial website http://jc.med.uu.nl/sdd
Publications 1. 2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19118302
2. 2010 survery results in http://www.ncbi.nlm.nih.gov/pubmed/20626848
3. 2911 results in http://www.ncbi.nlm.nih.gov/pubmed/21420908
Contact name Dr  Anne Marie G A  de Smet
  Address University Medical Center Utrecht, AZU
PO Box 85500
  City/town Amsterdam
  Zip/Postcode 3508 GA
  Country Netherlands
  Tel +31 (0)30 2509111
  Email a.desmet@azu.nl
Sponsor University Medical Centre Utrecht (Netherlands)
  Address PO Box 85500
  City/town Utrecht
  Zip/Postcode 3508 GA
  Country Netherlands
  Sponsor website: http://www.umcutrecht.nl/zorg/
Date applied 20/12/2005
Last edited 30/03/2011
Date ISRCTN assigned 20/12/2005
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