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Managing Injuries of the Neck
ISRCTN ISRCTN33302125
DOI 10.1186/ISRCTN33302125
ClinicalTrials.gov identifier
EudraCT number
Public title Managing Injuries of the Neck
Scientific title
Acronym MINT
Serial number at source HTA 02/35/02
Study hypothesis To estimate the clinical and cost effectiveness of a stepped care approach following acute injury.

A related study "Managing Injuries of the Neck Trial - Incentive" is registered with ISRCTN61305297.

Please note that, as of 11/05/2009, the anticipated end date has been updated from 31/10/2008 to 31/03/2009.
Lay summary Not provided at time of registration
Ethics approval Approved by UK Trent Multicentre Research Ethics Committee and by the Local Research Ethics Committee and the Research and Development Committee of each participating centre.
Study design Randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Acute neck sprain (whiplash)
Participants - inclusion criteria 1. People with Acute whiplash (<6 weeks), Whiplash Associated Disorder (WAD) grades I-III
2. Patients with persisting symptoms three weeks after their Emergency Department attendance
Participants - exclusion criteria 1. Age below 18
2. Fractures or dislocations of the spine and other bones
3. Head injuries with more than a transient loss of consciousness or with a Glasgow coma score of 12 or less at any stage of their assessment in hospital
4. Admission to in patient services
5. Severe psychiatric illness
Anticipated start date 01/11/2004
Anticipated end date 31/03/2009
Status of trial Completed
Patient information material
Target number of participants 4,800 patients in first step and 600 patients in second step
Interventions Stepped care approach.
1. Step One: The Whiplash Booklet versus usual care advice in Accident and Emergency (A&E)
2. Step Two: In patients with symptoms persisting at 3 weeks (WAD Grade I-III), supplementary treatment comprising either a package of physiotherapy treatments and re-enforcement of advice versus re-enforcement of advice provided at the initial A&E contact only
3. Step Three: The combined effect of the various treatments using a 2 by 2 factorial design
Primary outcome measure(s) Return to normal function will be assessed using Neck Disability Index
Secondary outcome measure(s) SF-12® Health Survey, Euroqol EQ-5D
Sources of funding NIHR Health Technology Assessment Programme - HTA (UK)
Trial website http://www2.warwick.ac.uk/fac/med/healthcom/emergencycare/research/whiplash/
Publications 1. 2007 protocol in http://www.ncbi.nlm.nih.gov/pubmed/17257408
2. 2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19700580
3. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/23241145
4. 2013 results in http://www.ncbi.nlm.nih.gov/pubmed/23260167
Contact name Prof  Sarah Elizabeth  Lamb
  Address Warwick Emergergency Care & Rehabilitation
Warwick Medical School
University of Warwick
Gibbet Hill Campus
  City/town Coventry
  Zip/Postcode CV4 7AL
  Country United Kingdom
  Tel +44 (0)24 7657 4658
  Fax +44 (0)24 7657 4657
  Email s.lamb@warwick.ac.uk
Sponsor Department of Health (UK)
  Address Quarry House
Quarry Hill
  City/town Leeds
  Zip/Postcode LS2 7UE
  Country United Kingdom
  Email Sheila.Greener@doh.gsi.gov.uk
  Sponsor website: http://www.dh.gov.uk/en/index.htm
Date applied 02/11/2004
Last edited 25/02/2013
Date ISRCTN assigned 02/11/2004
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