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Positive Online Weight Reduction Study (POWeR)
ISRCTN ISRCTN31685626
DOI 10.1186/ISRCTN31685626
ClinicalTrials.gov identifier
EudraCT number
Public title Positive Online Weight Reduction Study (POWeR)
Scientific title Positive Online Weight Reduction Study (POWeR): a randomised multicentre interventional prevention/process of care trial
Acronym POWeR
Serial number at source 9575
Study hypothesis Obesity is a major and rapidly rising public health threat. Recent NICE guidelines provide recommendations to implement lifestyle changes (diet and exercise) supported by behavioural techniques. Unfortunately, an average practice will have more than 1000 patients with obesity, and most practice staff have neither the training nor the time to implement intensive obesity management programmes based on 1:1 counselling, or even group counselling, to cope with such numbers. The problem will become worse as the obesity epidemic progresses. By providing an intervention which requires fewer resources for training and for intervention this study will allow a much greater group of patients to benefit both locally and nationally.

We have developed written behavioural manuals for both patient and practitioner. This study will create a less resource intensive intervention to support behavioural change by converting these materials into web format, taking advantage of a grant to our group which supports the development of generic web programming for behavioural interventions. After materials have been converted to web format, and are acceptable to patients and practitioners, we will then explore the impact of different levels of nurse support required to achieve effective weight change.
Lay summary Not provided at time of registration
Ethics approval IOW, Portsmouth and SE Hampshire Research Ethics Committee approved on the 13th September 2010 (ref: 10/H0501/46)
Study design Randomised multicentre interventional prevention/process of care trial
Countries of recruitment United Kingdom
Disease/condition/study domain Topic: Primary Care Research Network for England; Subtopic: Not Assigned; Disease: All Diseases
Participants - inclusion criteria 1. Patients aged over 18 years, either gender
2. Body mass index (BMI) greater than or equal to 30 (or 28 with hypertension or hypercholesterolaemia) documented in the GP case records
Participants - exclusion criteria 1. Current major mental problems (difficulty completing outcomes)
2. Very ill/unable to change diet (e.g. severe left ventricular failure [LVF])
3. Pregnancy/breast feeding
4. Perceived inability to walk 100 metres (i.e. physical activity difficult)
Anticipated start date 01/12/2010
Anticipated end date 31/05/2013
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants Planned sample size: 265
Interventions Phase 1:
Study 1: In-depth interviews will be carried out with up to 30 patients from 3 - 4 GP practices to elicit views of the intervention materials (including reactions to content and usability).

Study 2: Up to 5 focus groups will be held for health professionals with practice nurses and GPs from 10 - 20 practices. Participants will be invited to use the training materials and patient website prior to taking part in the focus group to stimulate discussion of the issues relating to content, format and feasibility.

Phase 2:
Pilot RCT: Patients will be offered:
1. Web access and email support
2. Minimal face to face support
3. Intensive face to face visits
4. Normal care

GP records will be reviewed for cost-effectiveness.
Primary outcome measure(s) Weight, measured at baseline, one month and end of study (6 months)
Secondary outcome measure(s) 1. EQ5D, measured at baseline, one month and 6 months
2. Food Frequency Questionnaire, measured at baseline, one month and 6 months
3. Godin Leisure Time Physical Activity Questionnaire, measured at baseline, one month and 6 months
4. GP record review, measured at the end of the study
5. Physical measurements, measured at baseline, one month and 6 months
Sources of funding National Institute for Health Research (NIHR) (UK) - Research for Patient Benefit (RfPB) programme (ref: PB-PG-0808-17077)
Trial website
Publications 2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/24886516
Contact name Mrs  Susan  Broomfield
  Address Primary Medical Care
Aldermoor Health Centre
Aldermoor Close
  City/town Southampton
  Zip/Postcode SO16 5ST
  Country United Kingdom
  Email seb4@soton.ac.uk
Sponsor University of Southampton (UK)
  Address Primary Medical Care
Aldermoor Health Centre
Aldermoor Close
  City/town Southampton
  Zip/Postcode SO16 5ST
  Country United Kingdom
  Sponsor website: http://www.soton.ac.uk/
Date applied 02/02/2011
Last edited 03/06/2014
Date ISRCTN assigned 02/02/2011
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