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Prevention of Dementia by Intensive Vascular Care
ISRCTN ISRCTN29711771
DOI 10.1186/ISRCTN29711771
ClinicalTrials.gov identifier
EudraCT number
Public title Prevention of Dementia by Intensive Vascular Care
Scientific title
Acronym Pre-DIVA
Serial number at source NTR523
Study hypothesis To investigate if interventions aimed at vascular risk factors reduce the incidence of dementia or the burden of functional disability in elderly.
Lay summary Not provided at time of registration
Ethics approval Received from local medical ethics committee
Study design Randomised open label triple blind active controlled parallel group trial
Countries of recruitment Netherlands
Disease/condition/study domain Dementia, Vascular complaints
Participants - inclusion criteria 1. Age: 70-78 years
2. No dementia
3. No other complaints with bad prognosis
4. No psychiatry
Participants - exclusion criteria 1. Diagnosis of dementia
2. Any factor that limits the probability of successful follow up (e.g. alcoholism, imminent emigration)
3. Any factor that limits life expectancy to less than 2 years
Anticipated start date 01/01/2006
Anticipated end date 01/01/2013
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants 3700
Interventions Intensive vascular care for elderly people (aged 70 through 78 years) by nurse practitioners in general practice compared to regular care.
Primary outcome measure(s) Incidence of dementia
Secondary outcome measure(s) Incidence of myocardial infarction, cebrovascular incidents and cardiovascular mortality.
Sources of funding 1. Former Voluntary Fund Insurance Reserves (Reserves Voormalige Vrijwillige Ziekenfondsverzekeringen [RVVZ]) (Netherlands)
2. Netherlands Organisation for Health Research and Development (ZonMw) (Netherlands)
3. Ministry of Public Health, Welfare and Sport (Ministerie van Volksgezondheid, Welzijn en Sport [VWS]) (Netherlands)
Trial website
Publications 1. 2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21930719
2. 2012 substudy results in http://www.ncbi.nlm.nih.gov/pubmed/22664551
Contact name Dr  M.  Jong-Putto, de
  Address Academic Medical Center
Clinical Trial Office Neurology
H2 -233
P.O. Box 22660
  City/town Amsterdam
  Zip/Postcode 1100 DD
  Country Netherlands
  Tel +31 (0)20 5664564
  Email m.putto@amc.uva.nl
Sponsor Academic Medical Centre (Netherlands)
  Address Department of Neurology
P.O. Box 22660
  City/town Amsterdam
  Zip/Postcode 1100 DD
  Country Netherlands
Date applied 14/02/2006
Last edited 24/08/2012
Date ISRCTN assigned 14/02/2006
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