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ISRCTN
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ISRCTN29126001
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DOI
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10.1186/ISRCTN29126001
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ClinicalTrials.gov identifier
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EudraCT number
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Public title
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Comparative efficacy of albendazole and mebendazole against hookworm infection in Laos
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Scientific title
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Comparative efficacy of Albendazole and Mebendazole against hookworm infection: Randomised, controlled trial in schoolchildren in Khamkeuth district, Bolikhamxay province, Laos
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Acronym
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AlMebLaos
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Serial number at source
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N/A
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Study hypothesis
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Albendazole (400 mg single dose) is more effective than mebendazole (500 mg single dose) in clearing hookworm infection.
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Lay summary
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Not provided at time of registration
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Ethics approval
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National Ethics Committee for Health Research, Vientiane, Laos. Date of approval: 01/04/2008 (ref: 170 /NECHR)
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Study design
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Randomised controlled trial
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Countries of recruitment
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Laos
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Disease/condition/study domain
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Hookworm infection, and other intestinal helminth infections
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Participants - inclusion criteria
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1. School-child age between 6 and 16 years, both male and female
2. Hookworm infected (at least one of four egg-positive Kato-Katz slide, established on 2 stool samples)
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Participants - exclusion criteria
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1. Pregnancy
2. Severe illness
3. Non-consent
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Anticipated start date
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28/04/2008
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Anticipated end date
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30/05/2008
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Status of trial
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Completed |
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Patient information material
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Not available in web format, please use the contact details below to request a patient information sheet
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Target number of participants
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190
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Interventions
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Mebendazole (500 mg, single dose, oral) vs albendzole (400 mg, single dose, oral) treatment.
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Primary outcome measure(s)
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Hookworm parasite clearance (no hookworm egg in four Kato-Katz slides taken on two stool samples) at 21-23 days after treatment
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Secondary outcome measure(s)
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Reduction of intensity of infection (reduction of mean number of hookworm eggs counted on four Kato-Katz slides taken on two different stool samples) at 21-23 days after treatment
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Sources of funding
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Swiss National Science Foundation (Switzerland)
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Trial website
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Publications
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1. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22235353
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Contact name
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Dr
Peter
Odermatt
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Address
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Swiss Tropical Institute
Department of Public Health and Epidemiology
Socinstrasse 57
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City/town
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Basel
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Zip/Postcode
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4002
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Country
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Switzerland
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Sponsor
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Swiss National Science Foundation (Switzerland)
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Address
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Wildhainweg 3
P.O. Box 8232
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City/town
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Bern
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Zip/Postcode
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3001
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Country
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Switzerland
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Sponsor website:
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http://www.snf.ch
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Date applied
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25/04/2008
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Last edited
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02/05/2012
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Date ISRCTN assigned
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09/10/2008
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