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ISRCTN
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ISRCTN27780786
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ClinicalTrials.gov identifier
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Public title
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Secondary prevention of cardiovascular disease in general practice.
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Scientific title
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Acronym
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N/A
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Serial number at source
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MC10
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Study hypothesis
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Patients with established coronary heart disease have a lower mortality rate and less morbidity if they make changes in their behaviour (smoking, diet, exercise, weight), and are given appropriate medication (aspirin, beta blockers, lipid lowering drugs etc).
Achieving these interventions involves collaboration between patients and families, hospital staff, and primary care teams which is often not done well.
The main aim of this study was to see if the use of specialist liaison nurses to co-ordinate care at hospital discharge and to support existing rehabilitation and primary care services was cost-effective in reducing morbidity and cardiovascular risk in the year after myocardial infarction.
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Heart disease
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Participants - inclusion criteria
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597 patients from 67 practices in Southampton and South-West Hampshire who had been admitted to hospital or attended a chest pain clinic with a myocardial infarct or recent-onset angina were recruited to the study. 38 patients died within 12 months.
Follow up rates were about 90%.
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Participants - exclusion criteria
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Does not match inclusion criteria
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Anticipated start date
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01/01/1995
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Anticipated end date
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01/07/1997
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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597
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Interventions
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1. Use of liaison nurses - sought to co-ordinate care, support the patient and family, support the practice nurses, and support the cardiac rehabilitation programme.
The liaison nurses were not involved with management of individual patients but sought to encourage the use of current models of behaviour change, achieve a structured programme for each patient, and promote the use of effective treatments.
2. No use of liaison nurses, i.e. standard care
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Primary outcome measure(s)
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1. At assessment demographic data and information on smoking and diet were collected. The patient's weight, height, blood pressure, and blood cholesterol were measured.
2. The three questionnaires asked about smoking, exercise, and diet; drug treatment; attendance at rehabilitation and other health services; and symptoms of pain and breathlessness.
3. Psychological state was assessed using the Hospital Anxiety and Depression scale
4. Quality of life using the Euroqual scale
5. At 12 months the clinical examination repeated the baseline measurements, together with a measurement of blood cotinine in those who had ever smoked, and a 6 minute exercise test.
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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NHS Cardiovascular Disease and Stroke National Research and Development Programme (UK)
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Trial website
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Publications
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1. 1998 results in http://www.ncbi.nlm.nih.gov/pubmed/10078796
2. 1999 results in http://www.ncbi.nlm.nih.gov/pubmed/10074017
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Contact name
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Prof
David
Mant
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Address
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Institute of Health Sciences
University of Oxford
Old Road
Headington
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City/town
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Oxford
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Zip/Postcode
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OX3 7LF
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Country
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United Kingdom
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Tel
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+44 (0)1865 226 770
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Fax
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+44 (0)1865 226 720
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Email
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david.mant@dphpc.ox.ac.uk
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Sponsor
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Record Provided by the NHS R&D 'Time-Limited' National Programme Register - Department of Health (UK)
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Address
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The Department of Health
Richmond House
79 Whitehall
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City/town
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London
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Zip/Postcode
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SW1A 2NL
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Country
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United Kingdom
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Tel
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+44 (0)20 7307 2622
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Fax
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+44 (0)20 7307 2623
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Email
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dhmail@doh.gsi.org.uk
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Sponsor website:
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http://www.doh.gov.uk
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Date applied
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23/01/2004
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Last edited
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20/11/2009
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Date ISRCTN assigned
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23/01/2004
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