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The effect of inspiratory muscle training intensities on pulmonary function and exercise capacity in healthy subjects
ISRCTN ISRCTN26277638
DOI 10.1186/ISRCTN26277638
ClinicalTrials.gov identifier
EudraCT number
Public title The effect of inspiratory muscle training intensities on pulmonary function and exercise capacity in healthy subjects
Scientific title The effect of inspiratory muscle training intensities on pulmonary function and exercise capacity in healthy subjects: a randomised controlled trial
Acronym N/A
Serial number at source 0622839
Study hypothesis Inspiratory muscle training performed at 80%, 60% and 40% of maximal intensity will result in changes in inspirator muscle function with 80% and 40% producing positive effects on exercise capacity and 80% producing positive effect on lung volumes.
Lay summary Not provided at time of registration
Ethics approval School of Health Care Studies R&D Committee approved on the 27th August 2007 (ref: REG2707)
Study design Randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Pulmonary function, exercise capacity
Participants - inclusion criteria Healthy, moderately trained subjects (aged 18 - 27 years, either sex). The rationale for the age range was so data could be compared to those obtained in a population of adults with cystic fibrosis.
Participants - exclusion criteria Pre-existing respiratory disease
Anticipated start date 04/02/2008
Anticipated end date 09/05/2008
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants 40
Interventions Intervention: inspiratory muscle training at 80%, 60%, 40% of maximum sustained inspiratory pressure. The training intervention was performed 3 times a week over an eight week period. Each training session took 30 minutes to complete.
Control: no participation in any form of training throughout the duration of the study.

The control group and the three training groups were assessed at the begining of the trial (the initial screening visit) and all measurements (excluding body composition) were repeated at the trial conclusion (at the end of an eight week training period for the three training groups and the control group).
Primary outcome measure(s) 1. Lung volumes (vital capacity and total lung capacity)
2. Exercise capacity (cycle ergometry)
3. Inspiratory pressure

Measurements were taken before the training intervention and then at the cessation of training (i.e., following the 8 weeks of training).
Secondary outcome measure(s) No secondary outcome measures
Sources of funding Physiotherapy Research Foundation (UK) - Chartered Society of Physiotherapy (ref: PRF/97/5)
Trial website
Publications 1. 2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21493747
Contact name Dr  Stephanie  Enright
  Address Deapartment of Physiotherapy
School of health Care Studies
Cardiff University
  City/town Cardiff
  Zip/Postcode CF14 4XN
  Country United Kingdom
  Tel +44 (0)29 2068 7558
  Fax +44 (0)29 2068 7567
  Email enrights@cardiff.ac.uk
Sponsor Cardiff University (UK)
  Address Heath Park Campus
  City/town Cardiff
  Zip/Postcode CF14 4XN
  Country United Kingdom
  Tel +44 (0)29 2068 7558
  Fax +44 (0)29 2068 7567
  Email enrights@cardiff.ac.uk
  Sponsor website: http://www.cardiff.ac.uk
Date applied 11/05/2009
Last edited 15/08/2011
Date ISRCTN assigned 15/07/2009
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