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Myocardial Injury following Coronary Artery bypass Surgery versus percutaneous coronary Angioplasty with stents: a randomised controlled trial using biochemical markers and cardiovascular magnetic resonance imaging
ISRCTN ISRCTN25699844
DOI 10.1186/ISRCTN25699844
ClinicalTrials.gov identifier
EudraCT number
Public title Myocardial Injury following Coronary Artery bypass Surgery versus percutaneous coronary Angioplasty with stents: a randomised controlled trial using biochemical markers and cardiovascular magnetic resonance imaging
Scientific title
Acronym MICASA
Serial number at source 06/Q1606/19
Study hypothesis In patients with multivessel and/or left main Coronary Artery Disease (CAD), Percutaneous Coronary Intervention (PCI) compared with Coronary Artery Bypass Grafting (CABG) results in less frequent heart muscle injury, as measured by cardiac troponin I and delayed enhancement Magnetic Resonance Imaging (MRI). Secondarily, that percutaneous coronary intervention offers equivalent revascularisation compared with coronary artery bypass surgery as measured by MRI perfusion.
Lay summary Not provided at time of registration
Ethics approval Ethics approval received from the Oxfordshire Local Research Ethics Committee on the 17th March 2006 (ref: 06/Q1606/19).
Study design Randomised clinical trial
Countries of recruitment United Kingdom
Disease/condition/study domain Multivessel coronary artery disease
Participants - inclusion criteria 1. Patients with greater than or equal to two vessel CAD (greater than or equal to 50% stenosis) including the Left Anterior Descending (LAD), and/or a functionally significant left main stem stenosis of 50% or more
2. Equivalent revascularisation can be provided by PCI and CABG
3. Angina (stable or unstable), or documented silent ischaemia on functional stress testing
Participants - exclusion criteria 1. Contraindication to aspirin or clopidogrel
2. Women of childbearing potential
3. Non-viable myocardium in the area subtended by diseased vessels
4. Patients requiring concomitant cardiac surgery
5. Acute myocardial infarction
Anticipated start date 01/06/2006
Anticipated end date 31/12/2007
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants 60
Interventions Coronary artery bypass grafting versus percutaneous coronary intervention.
Primary outcome measure(s) The frequency of new myocardial injury following PCI and CABG as assessed by biochemical markers (troponin I) and MRI.
Secondary outcome measure(s) 1. Total amount of new myocardial necrosis (in grams) assessed by MRI
2. Change in left ventricular function assessed by MRI
Sources of funding Cordis, a division of Johnson & Johnson Medical Ltd (UK) - Dr William van Gaal is funded by the Clinical Cardiology Research Scholarship
Trial website
Publications 1. 2011 results in: http://www.ncbi.nlm.nih.gov/pubmed/21205592
2. 2011 results in: http://www.ncbi.nlm.nih.gov/pubmed/21292125
3. 2011 results in: http://www.ncbi.nlm.nih.gov/pubmed/21908890
4. 2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/23696598
Contact name Dr  Adrian  Banning
  Address Department of Cardiology
Level 2
Headley Way
  City/town Headington
  Zip/Postcode OX3 9DU
  Country United Kingdom
  Tel +44 (0)1865 228 934
  Fax +44 (0)1865 220 585
  Email adrian.banning@orh.nhs.uk
Sponsor Oxford Radcliffe Hospitals NHS Trust (UK)
  Address Research and Development
Manor House
John Radcliffe Hospital
Headley Way
  City/town Headington
  Zip/Postcode OX3 9DU
  Country United Kingdom
Date applied 23/04/2006
Last edited 24/01/2014
Date ISRCTN assigned 06/06/2006
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