|
ISRCTN
|
ISRCTN24647151
|
|
ClinicalTrials.gov identifier
|
|
|
Public title
|
UKCCCR trial to study the effect on breast cancer mortality of annual mammographic screening starting at age 40
|
|
Scientific title
|
|
|
Acronym
|
The 'Age' trial
|
|
Serial number at source
|
G9000793
|
|
Study hypothesis
|
To determine the effectiveness of mammographic screening starting at age 40, compared with starting at age 50, in reducing mortality from breast cancer.
|
|
Ethics approval
|
Not provided at time of registration
|
|
Study design
|
Randomised controlled trial
|
|
Countries of recruitment
|
United Kingdom
|
|
Disease/condition/study domain
|
Breast cancer
|
|
Participants - inclusion criteria
|
Women aged 40-41 identified from HA registers
|
|
Participants - exclusion criteria
|
Women under care for breast cancer may be removed from the prior notification list by the GPs prior to randomisation
|
|
Anticipated start date
|
30/07/1990
|
|
Anticipated end date
|
31/12/2010
|
|
Status of trial
|
Ongoing
|
|
Patient information material
|
|
|
Target number of participants
|
160,000
|
|
Interventions
|
Women in the intervention group are offered annual screening by mammography until the year of their 48th birthday. Screening is by 2-view mammography at 1st screen and single view subsequently. All women in both intervention and control groups will be invited for screening in the NHSBSP between the age of 50-52.
|
|
Primary outcome measure(s)
|
Deaths from breast cancer in women free of the disease at trial entry in the two groups. Information on prognostic factors of all breast cancers is also collected.
|
|
Secondary outcome measure(s)
|
Not provided at time of registration
|
|
Sources of funding
|
Medical Research Council (UK)
|
|
Trial website
|
|
|
Publications
|
Results: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17161727
Protocol: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids= 10572845
Results: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids= 11979379
|
|
Contact name
|
Dr
SM
Moss
|
|
Address
|
Cancer Screening Evaluation Unit
Institute of Cancer Research
Section of Epidemiology
D Block Cotswold Road
|
|
City/town
|
Sutton Surrey
|
|
Zip/Postcode
|
SM2 5NG
|
|
Country
|
United Kingdom
|
|
Email
|
|
|
Sponsor
|
Medical Research Council (UK)
|
|
Address
|
20 Park Crescent
|
|
City/town
|
London
|
|
Zip/Postcode
|
W1B 1AL
|
|
Country
|
United Kingdom
|
|
Tel
|
+44 (0)20 7636 5422
|
|
Fax
|
+44 (0)20 7436 6179
|
|
Email
|
clinical.trial@headoffice.mrc.ac.uk
|
|
Sponsor website:
|
http://www.mrc.ac.uk
|
|
Date applied
|
06/04/2000
|
|
Last edited
|
07/02/2007
|
|
Date ISRCTN assigned
|
06/04/2000
|
