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ISRCTN
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ISRCTN24219839
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ClinicalTrials.gov identifier
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Public title
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Trial of PACEBOM versus CHOP in histologically aggressive non-Hodgkins lymphoma
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Scientific title
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Acronym
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N/A
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Serial number at source
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LY3
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Study hypothesis
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Not provided at time of registration
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Lymphoma (non-Hodgkins)
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Participants - inclusion criteria
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1. Aged 16 to 69 years
2. Previously untreated histologically aggressive lymphoma with a large cell component: Diffuse large cell, Diffuse immunoblastic, Diffuse mixed cell
3. Stages II-IV
4. No contraindications to treatment protocols
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Participants - exclusion criteria
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Patients with Burkitt's and lymphoblastic lymphoma to be excluded
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Anticipated start date
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01/11/1987
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Anticipated end date
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31/10/1992
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Status of trial
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Completed
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Patient information material
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Target number of participants
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Not provided at time of registration
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Interventions
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Patients were randomised to one of two regimens:
1. CHOP Regimen: Multi-drug chemotherapy with cyclophosphamide, hydroxydaunorubicin, vincristine and prednisolone (CHOP) repeated every 28 days. A minimum of six courses to be given with two courses beyond the attainment of complete response
2. PACEBOM Regimen: Multi-drug chemotherapy with prednisolone, adriamycin, cyclophosphamide and etoposide (PACE) alternating every 7 days with bleomycin, vincristine and methotrexate (BOM). Six cycles of PACE and five of BOM to be given
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Primary outcome measure(s)
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Not provided at time of registration
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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1. Cancer Research UK
2. Lymphoma Research Trust
3. Lisa Lear Fund
4. Isle of Man Anti-Cancer Association
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Trial website
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Publications
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1996 results in http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8688344
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Contact name
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Dr
-
-
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Address
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UKCCCR Register Co-ordinator
MRC Clinical Trials Unit
222 Euston Road
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City/town
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London
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Zip/Postcode
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NW1 2DA
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Country
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United Kingdom
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Sponsor
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Cancer Research UK (CRUK) (UK)
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Address
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PO Box 123
Lincoln's Inn Fields
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City/town
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London
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Zip/Postcode
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WC2A 3PX
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Country
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United Kingdom
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Tel
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+44 (0)20 7317 5186
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Fax
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+44 (0)20 7487 4302
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Email
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kate.law@cancer.org.uk
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Sponsor website:
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http://www.cancer.org.uk
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Date applied
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01/07/2001
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Last edited
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19/12/2007
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Date ISRCTN assigned
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01/07/2001
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