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Multicentre randomised controlled trial comparing uterine artery embolisation with surgical treatment for uterine fibroids
ISRCTN ISRCTN23023665
DOI 10.1186/ISRCTN23023665
ClinicalTrials.gov identifier
EudraCT number
Public title Multicentre randomised controlled trial comparing uterine artery embolisation with surgical treatment for uterine fibroids
Scientific title
Acronym REST
Serial number at source czh/4/1
Study hypothesis Compare results of embolisation with surgery for uterine fibroids.
Lay summary Lay summary under review 3
Ethics approval Ethics approval received from the Multicentre Reseach Ethics Committee (MREC) of Edinburgh on the 11th May 2000 (ref: MREC/00/0/29).
Study design Open randomised controlled trial allocation 2:1 in favour of new intervention
Countries of recruitment United Kingdom
Disease/condition/study domain Uterine fibroids
Participants - inclusion criteria Women with symptomatic fibroid who would normally undergo surgery for treatment.
Participants - exclusion criteria 1. Pregnancy
2. Unable to image with magnetic resonance imaging (MRI)
3. Fibroid size less than 2 cm
4. Subserosal fibroid on a stalk
Anticipated start date 01/11/2000
Anticipated end date 01/09/2010
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants 200
Interventions Uterine artery embolisation versus surgical treatment
Primary outcome measure(s) The 36-item Short Form health survey (SF-36) quality of life questionnaire.
Secondary outcome measure(s) 1. Symptom scores
2. Complications
3. Return to lifestyle events
4. Pain scores
5. Cost analysis
Sources of funding Chief Scientist Office (UK) (ref: CZH/4/1)
Trial website
Publications 1. 2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17251532
2. 2010 results in www.ncbi.nlm.nih.gov/pubmed/20465558
3. 2011 5-year results in http://www.ncbi.nlm.nih.gov/pubmed/21481151
Contact name Prof  Jonathan  Moss
  Address Department of Radiology
Gartnavel General Hospital
1053 Great Western Road
  City/town Glasgow
  Zip/Postcode G12 OYN
  Country United Kingdom
  Tel +44 (0)141 211 3115
  Fax +44 (0)141 211 3471
  Email jon.moss@northglasgow.scot.nhs.uk
Sponsor Greater Glasgow Health Board (North Glasgow University Hospitals Division) (UK)
  Address 300 Balgray Hill Road
  City/town Glasgow
  Zip/Postcode G21 3UR
  Country United Kingdom
  Tel +44 (0)141 211 1817
  Fax +44 (0)141 211 1814
  Email judith.godden@northglasgow.scot.nhs.uk
  Sponsor website: http://www.ngt.org
Date applied 08/03/2006
Last edited 02/08/2012
Date ISRCTN assigned 16/03/2006
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