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ISRCTN
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ISRCTN20662850
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ClinicalTrials.gov identifier
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Public title
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Influence of Hyperglycaemia on Mononuclear Cell DNA Integrity and Gene Expression in Relation to Cardiovascular Disease Risk
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Scientific title
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Acronym
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N/A
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Serial number at source
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N0547130898
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Study hypothesis
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The expression of cardiovascular disease (CVD)-risk-associated genes will be increased at baseline in patients with Type 2 diabetes compared with non-diabetic individuals, and the expression of these genes will be up-regulated following an acute glucose load, and will be repressed following antioxidant supplementation in patients with Type 2 diabetes.
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Nutritional, Metabolic, Endocrine: Diabetes
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Participants - inclusion criteria
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30 patients with type 2 diabetes and 30 controls
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Participants - exclusion criteria
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Not provided at time of registration
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Anticipated start date
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01/10/2003
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Anticipated end date
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01/10/2005
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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60
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Interventions
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Not provided at time of registration
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Primary outcome measure(s)
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Controls will be recruited from the Institute of Food Research's (IFR's) Human Nutrition Unit volunteer database, the Diabetes Centre database and by media reporting (local newspaper feature).
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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East Norfolk and Waveney Research Consortium - Norfolk and Norwich University Hospital/Norwich PCT (UK)
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Trial website
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Publications
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Contact name
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Dr
Mike
Sampson
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Address
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Consultant Physician
Department of Diabetes and Endocrinology
Level 3, East Wing
Norfolk and Norwich University Hospital NHS Trust
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City/town
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Norwich
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Zip/Postcode
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NR4 7UY
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Country
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United Kingdom
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Tel
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+44 (0)1603 287094
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Fax
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+44 (0)1603 287320
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Email
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mike.sampson@nnuh.nhs.uk
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Sponsor
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Record Provided by the NHSTCT Register - 2004 Update - Department of Health (UK)
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Address
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The Department of Health,
Richmond House,
79 Whitehall
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City/town
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London
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Zip/Postcode
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SW1A 2NL
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Country
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United Kingdom
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Tel
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+44 (0)20 7307 2622
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Email
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dhmail@doh.gsi.org.uk
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Sponsor website:
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http://www.dh.gov.uk/Home/fs/en
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Date applied
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30/09/2004
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Last edited
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15/02/2010
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Date ISRCTN assigned
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30/09/2004
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