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ISRCTN
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ISRCTN17931175
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DOI
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10.1186/ISRCTN17931175
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ClinicalTrials.gov identifier
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EudraCT number
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Public title
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A joint MRC/European Organisation for Research and Treatment of Cancer (EORTC) study of radiotherapy for low grade astrocytomas and oligodendrogliomas
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Scientific title
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Acronym
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N/A
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Serial number at source
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BR04
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Study hypothesis
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To assess the value of post-operative radiotherapy in the management of low grade (1 & 2) astrocytoma and oligodendroglioma.
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Lay summary
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http://www.ctu.mrc.ac.uk/research_areas/study_details.aspx?s=100
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Ethics approval
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Not provided at time of registration.
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Study design
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Randomised controlled trial
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Countries of recruitment
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Europe
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Disease/condition/study domain
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Cancer
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Participants - inclusion criteria
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1. Age 16-66
2. World Health Organisation (WHO) performance status 0-2
3. Neurosurgery within past 8 weeks
4. No previous malignancy
5. No previous treatment except surgery
6. Corticosteroids, anticonvulsants or diuretics
7. No condition likely to prejudice treatment or follow up
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Participants - exclusion criteria
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History of cardiac disease
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Anticipated start date
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01/08/1986
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Anticipated end date
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30/06/1996
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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250
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Interventions
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Two groups - post-operative radiotherapy and no post-operative radiotherapy.
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Primary outcome measure(s)
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Survival time, Morbidity, Time to progression
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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Medical Research Council (MRC) (UK)
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Trial website
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Publications
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2005 results in http://www.ncbi.nlm.nih.gov/pubmed/16168780
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Contact name
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Dr
Hannah
Brooks
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Address
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MRC Clinical Trials Unit
222 Euston Road
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City/town
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London
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Zip/Postcode
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NW1 2DA
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Country
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United Kingdom
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Email
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Sponsor
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Medical Research Council (MRC) (UK)
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Address
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20 Park Crescent
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City/town
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London
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Zip/Postcode
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W1B 1AL
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Country
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United Kingdom
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Tel
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+44 (0)20 7636 5422
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Fax
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+44 (0)20 7436 6179
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Email
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clinical.trial@headoffice.mrc.ac.uk
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Sponsor website:
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http://www.mrc.ac.uk
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Date applied
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28/02/2001
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Last edited
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04/08/2011
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Date ISRCTN assigned
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28/02/2001
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