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ISRCTN
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ISRCTN17465143
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ClinicalTrials.gov identifier
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Public title
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Ultra low dose anticoagulation in atrial fibrillation
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Scientific title
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Acronym
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N/A
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Serial number at source
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MC7
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Study hypothesis
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Previous studies have demonstrated increased markers of thrombogenesis in patients with atrial fibrillation (AF), suggesting the presence of a hypercoaguable or prothromobotic state. The objective of this study was to determine the effects of introducing ultra-low-dose warfarin (1 mg), conventional warfarin, and aspirin (300 mg) therapy on thrombogenesis and platelet activation in AF.
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Heart disease
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Participants - inclusion criteria
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Patients with atrial fibrillation
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Participants - exclusion criteria
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Does not match inclusion criteria
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Anticipated start date
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01/04/1994
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Anticipated end date
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01/04/1996
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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Not provided at time of registration
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Interventions
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3 treatment arms:
1. Ultra-low-dose warfarin (1 mg)
2. Conventional warfarin
3. Aspirin (300 mg)
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Primary outcome measure(s)
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Platelet activation
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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NHS Cardiovascular Disease and Stroke National Research and Development Programme (UK)
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Trial website
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Publications
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Contact name
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Prof
Gareth
Beevers
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Address
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University Department of Medicine
City Hospital
Dudley Rd
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City/town
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Birmingham
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Zip/Postcode
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B18 7QH
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Country
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United Kingdom
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Tel
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+44 (0)121 507 5080
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Email
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Sponsor
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Record Provided by the NHS R&D 'Time-Limited' National Programme Register - Department of Health (UK)
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Address
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The Department of Health
Richmond House
79 Whitehall
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City/town
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London
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Zip/Postcode
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SW1A 2NL
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Country
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United Kingdom
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Tel
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+44 (0)20 7307 2622
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Fax
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+44 (0)20 7307 2623
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Email
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dhmail@doh.gsi.org.uk
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Sponsor website:
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http://www.doh.gov.uk
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Date applied
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23/01/2004
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Last edited
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21/12/2009
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Date ISRCTN assigned
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23/01/2004
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