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Collaborative Care: Depression Initiative in Primary care
ISRCTN ISRCTN15266438
DOI 10.1186/ISRCTN15266438
ClinicalTrials.gov identifier
EudraCT number
Public title Collaborative Care: Depression Initiative in Primary care
Scientific title
Acronym CC:DIP
Serial number at source N/A
Study hypothesis The aim of the current Randomised Clinical Trial (RCT) is a cost-effectiveness analyses of a collaborative care approach compared to Care As Usual (CAU). The collaborative care approach is expected to be more effective and cost-effective than CAU.
Lay summary Not provided at time of registration
Ethics approval Study approved by the Medical Ethical Board of the Free University Medical Centre, Amsterdam, the Netherlands (reference number: protocol 06.158). Full approval of study design received on the 11th December 2006.
Study design Randomised controlled parallel armed trial
Countries of recruitment Netherlands
Disease/condition/study domain Depressive disorders
Participants - inclusion criteria The aim is to include patients who are diagnosed with major depressive disorder and who dysfunction due to the depressive disorder (i.e. loss of role in daily life).
Participants - exclusion criteria 1. Suicidal, psychotic or suffering from dementia
2. Have insufficient knowledge of Dutch to fill in the questionnaires
3. Are addicted to drugs or alcohol
4. Already receive psychiatric treatment
5. Less than 18 years old
Anticipated start date 01/12/2006
Anticipated end date 01/12/2010
Status of trial Completed
Patient information material
Target number of participants 240
Interventions The collaborative care approach includes care management, contracting, adherence improving strategies, manual guided self help and lifestyle interventions, Problem Solving Treatment (PST), and an antidepressant treatment algorithm; the treatment plan is set based on patient preferences.
Primary outcome measure(s) The primary outcome measure is response.
Secondary outcome measure(s) 1. Remission as measured by the Patient Health Questionnaire (PHQ-9) and Inventory of Depressive Symptomatology (Self-Reported) (IDS-SR).
2. Effect of chronic physical illness as an effect modifier.
3. Cost-effectiveness as measured with the Trimbos/iMTA questionnaire for Costs associated with Psychiatric illness (TiC-P), EuroQoL (EQ-5D) questionnaire and the Short Form health survey (SF-36).
Sources of funding Foundation Reserves Voormalige Vrijwillige Ziekenfondsverzekering (RVVZ) (The Netherlands)
Trial website
Publications 2013 secondary data analysis in: http://www.ncbi.nlm.nih.gov/pubmed/23438706
2013 results in: http://www.ncbi.nlm.nih.gov/pubmed/23068021
Contact name Ms  Marjoliek  Ijff
  Address Trimbos-instituut/Netherlands institute of Mental Health and Addiction
Da Costakade 45
P.O. Box 725
  City/town Utrecht
  Zip/Postcode 3500 AS
  Country Netherlands
  Tel +31 (0)30 2971185
  Fax +31 (0)30 2971111
  Email mijff@trimbos.nl
Sponsor Trimbos-institute/Netherlands Institute of Mental Health and Addiction (The Netherlands)
  Address P.O. Box 725
  City/town Utrecht
  Zip/Postcode 3500 AS
  Country Netherlands
  Tel +31 (0)30 2971100
  Fax +31 (0)30 2971111
  Email info@trimbos.nl
  Sponsor website: http://www.trimbos.nl/default37.html
Date applied 01/12/2006
Last edited 27/08/2013
Date ISRCTN assigned 01/12/2006
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