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Cognitive behaviour therapy for excessive worry over health in medical patients
ISRCTN ISRCTN14565822
DOI 10.1186/ISRCTN14565822
ClinicalTrials.gov identifier
EudraCT number
Public title Cognitive behaviour therapy for excessive worry over health in medical patients
Scientific title Cognitive behaviour therapy for Health Anxiety in Medical Patients
Acronym CHAMP
Serial number at source HTA 07/01/26
Study hypothesis Cognitive behaviour therapy adapted for health anxiety is a cost-effective way of treating patients with significant health anxiety in medical clinics.
Lay summary Not provided at time of registration
Ethics approval Nottingham Research Ethics Committee 1. Date of approval: 13/06/2008 (ref: 08/H0403/56)
Study design Randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Hypochondriasis/ mental health
Participants - inclusion criteria Patients attending four medical specialty clinics (in cardiology, respiratory medicine, gastroenterology and endocrinology) who:
1. Have significant health anxiety (score of 20 or more on the Health Anxiety Inventory)
2. Are aged between 16 and 75 (both males and females)
3. Are living independently
4. Are permanent residents in the area
5. Have sufficient understanding of English to read and complete the questionnaires
6. Give written consent for the interviews, including audiotaping of half the sessions
7. Give written consent for access to their medical records
Participants - exclusion criteria Patients who are:
1. Considered too ill in medical terms by their consultants to be considered for the study
2. In the process of being investigated for significant pathology and for whom cognitive behaviour therapy might confuse or cause distress
3. Those who have significant cognitive impairment
Anticipated start date 01/10/2008
Anticipated end date 30/09/2012
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants 465
Interventions Arm 1: Cognitive behaviour therapy adapted for health anxiety (Warwick/ Salkovskis model). Treatment will be given for between 5 and 10 one hour sessions for each patient, and will address abnormal worries about health and ways of overcoming them.

Arm 2: Single explanatory interview of the nature of health anxiety. This will be a single interview of 45 minutes describing the nature of health anxiety and how it tends to be perpetuated.

Duration of interventions: up to 6 months
Duration of follow-up: 2 years
Primary outcome measure(s) Reduction in health anxiety scores 1 year after randomisation.
Secondary outcome measure(s) 1. Reduction in health anxiety scores 2 years after randomisation
2. Presence or absence of diagnosis of hypochondriasis at 1 and 2 years after randomisation
3. Reduction in generalised anxiety and depression, assessed using the Hospital Anxiety and Depression Scale (HADS) at 1 and 2 years after randomisation
4. Improvement in social function and quality of life, assessed using the Social Functioning Questionnaire (SFQ) and Euroqol EQ-5D at 1 and 2 years after randomisation
5. Total costs of health care (primary and secondary) 1 and 2 years after randomisation
6. Change in presenteeism and absenteeism at work 1 and 2 years after randomisation
Sources of funding NIHR Health Technology Assessment Programme - HTA (UK)
Trial website
Publications 2011 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/21672205
2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/24139977
Contact name Prof  Peter  Tyrer
  Address Department of Psychological Medicine
St Dusntan's Road
  City/town London
  Zip/Postcode W6 8RP
  Country United Kingdom
  Tel +44 (0)207 386 1237
  Email p.tyrer@imperial.ac.uk
Sponsor Imperial College London (UK)
  Address Charing Cross Campus
St Dunstan's Road
  City/town London
  Zip/Postcode W6 8RP
  Country United Kingdom
  Tel +44 (0)207 386 1233
  Fax +44 (0)207 386 1216
  Email gary.roper@imperial.ac.uk
  Sponsor website: http://www3.imperial.ac.uk
Date applied 17/06/2008
Last edited 12/02/2014
Date ISRCTN assigned 20/06/2008
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