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ISRCTN
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ISRCTN14031168
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ClinicalTrials.gov identifier
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NCT00122811
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Public title
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HYpertension in the Very Elderly Trial
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Scientific title
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Acronym
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HYVET
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Serial number at source
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RG/97010
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Study hypothesis
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To assess the benefits of treating very elderly patients with hypertension.
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Lay summary
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Ethics approval
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Approved by the relevent central and local ethics committies
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Hypertension
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Participants - inclusion criteria
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1. People 80 years old and above
2. Sustained systolic pressure 160 - 199 mmHg and diastolic (phase V) pressure 90 - 109 mmHg
3. No evidence of renal failure or co-morbidity requiring anti-hypertensive treatment
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Participants - exclusion criteria
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Does not comply with above inclusion criteria.
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Anticipated start date
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01/01/2001
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Anticipated end date
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31/12/2009
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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2100
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Interventions
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Two treatment groups:
1. Placebo
2. Indapamide Sustained Release (SR) 1.5 mg plus perindopril 2 - 4 mg if required.
Goal: diastolic blood pressure less than 80 mmHg with systolic pressure less than 150 mmHg.
The patients are followed-up both according to clinical need and every 3 months in the first year and every 6 months thereafter.
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Primary outcome measure(s)
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Stroke events (fatal and non-fatal).
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Secondary outcome measure(s)
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1. Total mortality
2. Cardiovascular mortality
3. Cardiac mortality
4. Stroke mortality
5. Skeletal fracture
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Sources of funding
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1. British Heart Foundation (UK) (ref: RG/97010)
2. Institut de Recherches Internationales Servier (France)
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Trial website
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Publications
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1. 2001 main trial protocol in http://www.ncbi.nlm.nih.gov/pubmed/11302283
2. 2006 sub-study protocol in http://www.ncbi.nlm.nih.gov/pubmed/17177983
3. 2008 results in http://www.ncbi.nlm.nih.gov/pubmed/18378519
4. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20497949
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Contact name
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Professor
CJ
Bulpitt
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Address
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Care of the Elderly
Division of Medicine
ICSM at Hammersmith Hospital
Du Cane Road
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City/town
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London
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Zip/Postcode
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W12 0NN
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Country
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United Kingdom
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Tel
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+44 (0)20 8383 3959
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Fax
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+44 (0)20 8743 0798
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Email
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c.bulpitt@ic.ac.uk
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Sponsor
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British Heart Foundation (UK)
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Address
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14 Fitzhardinge Street
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City/town
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London
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Zip/Postcode
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W1H 6DH
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Country
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United Kingdom
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Tel
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+44 (0)20 7935 0185
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Fax
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+44 (0)20 7486 5820
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Email
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research@bhf.org.uk
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Sponsor website:
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http://www.bhf.org.uk/
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Date applied
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18/11/2001
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Last edited
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05/08/2010
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Date ISRCTN assigned
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18/11/2001
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