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ISRCTN
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ISRCTN13275753
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ClinicalTrials.gov identifier
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Public title
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Randomised placebo controlled trial of antihypertensive agents for the prevention of cardiovascular complications of hypertension
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Scientific title
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Acronym
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N/A
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Serial number at source
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N/A
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Study hypothesis
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That treatment with diuretic or beta-blocker in hypertensive people aged between 65 and 74 reduces risk of stroke, coronary heart disease and death.
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Lay summary
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Ethics approval
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Not provided at time of registration.
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Hypertension
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Participants - inclusion criteria
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Men and women aged 65-74 at recruitment in 226 general practices in the Medical Research Council's General Practice Research Framework. Systolic blood pressure 160-209 mmHg and diastolic pressure less than 115 mmHg.
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Participants - exclusion criteria
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Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; impaired renal function; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease including malignant hypertension.
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Anticipated start date
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01/03/1982
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Anticipated end date
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01/03/1987
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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4396 participants
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Interventions
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Amiloride, hydrochlorothiazide compared with placebo; atenolol compared with placebo.
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Primary outcome measure(s)
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Stroke, coronary events, deaths from all causes.
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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Medical Research Council (UK)
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Trial website
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Publications
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1985 results in http://www.ncbi.nlm.nih.gov/pubmed/2861880
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Contact name
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Prof
Tom
Meade
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Address
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Non-communicable Disease Epidemiology Unit
London School of Hygiene & Tropical Medicine
Keppel Street
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City/town
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London
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Zip/Postcode
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WC1E 7HT
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Country
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United Kingdom
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Email
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tom.meade@lshtm.ac.uk
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Sponsor
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Sponsor not defined - Record provided by the Medical Research Council (UK)
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Address
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20 Park Crescent
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City/town
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London
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Zip/Postcode
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W1B 1AL
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Country
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United Kingdom
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Email
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tom.meade@lshtm.ac.uk
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Date applied
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07/09/2005
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Last edited
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19/05/2011
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Date ISRCTN assigned
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08/09/2005
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