|
ISRCTN
|
ISRCTN11033714
|
|
ClinicalTrials.gov identifier
|
|
|
Public title
|
Low-dose doxycycline in the treatment of periodontitis in smokers
|
|
Scientific title
|
|
|
Acronym
|
N/A
|
|
Serial number at source
|
N/A
|
|
Study hypothesis
|
Not provided at time of registration.
|
|
Lay summary
|
|
|
Ethics approval
|
Not provided at time of registration.
|
|
Study design
|
Randomised controlled trial
|
|
Countries of recruitment
|
United Kingdom
|
|
Disease/condition/study domain
|
Periodontology
|
|
Participants - inclusion criteria
|
1. Smokers unable to quit
2. Moderate-severe chronic periodontitis
3. Age 30-70
|
|
Participants - exclusion criteria
|
Not provided at time of registration.
|
|
Anticipated start date
|
15/10/2000
|
|
Anticipated end date
|
15/10/2005
|
|
Status of trial
|
Completed |
|
Patient information material
|
|
|
Target number of participants
|
Not provided at time of registration.
|
|
Interventions
|
1. Non-surgical periodontal therapy plus twice daily 20 mg doxycycline for 3 months
2. Non-surgical periodontal therapy plus twice daily placebo for 3 months
|
|
Primary outcome measure(s)
|
Not provided at time of registration.
|
|
Secondary outcome measure(s)
|
Not provided at time of registration.
|
|
Sources of funding
|
Mainly self-supported: design, conduct, analysis and reporting are independent of industry. Biochemical analyses funded by CollaGenex Inc.
|
|
Trial website
|
|
|
Publications
|
2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17324155
|
|
Contact name
|
Dr
Ian
Needleman
|
|
Address
|
Department of Periodontology
Eastman Dental Institute for Oral Health Care Sciences
University College London
256 Gray's Inn Road
|
|
City/town
|
London
|
|
Zip/Postcode
|
WC1X 8LD
|
|
Country
|
United Kingdom
|
|
Tel
|
+44 (0) 20 7915 2340
|
|
Fax
|
+44 (0) 20 7915 2340
|
|
Email
|
i.needleman@eastman.ucl.ac.uk
|
|
Sponsor
|
CollaGenex Pharmaceuticals Inc. (USA)
|
|
Address
|
41 University Drive
|
|
City/town
|
Newtown
|
|
Zip/Postcode
|
PA 18940
|
|
Country
|
United States of America
|
|
Sponsor website:
|
http://www.collagenex.com
|
|
Date applied
|
15/10/2002
|
|
Last edited
|
24/11/2010
|
|
Date ISRCTN assigned
|
15/10/2002
|
