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ISRCTN
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ISRCTN10730637
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ClinicalTrials.gov identifier
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Public title
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Stop Stroke: The South London Secondary Prevention Programme
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Scientific title
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Acronym
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Stop Stroke
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Serial number at source
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1824/1845
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Study hypothesis
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To test the efficacy of a complex secondary prevention intervention on improving post stroke risk factor control. The study uses a cluster randomised controlled trial design with 120 general practices randomised at the start of the trial. All participants at a given practice (patients, carers and primary care staff) receive either the intervention or usual care.
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Lay summary
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Ethics approval
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Not provided at time of registration.
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Stroke
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Participants - inclusion criteria
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All patients with a diagnosis of first-in-a-lifetime stroke living in Lambeth and Southwark.
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Participants - exclusion criteria
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Patients must be alive six weeks post stroke, identified by the study team within six months of stroke and registered with a general practitioner.
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Anticipated start date
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21/07/2003
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Anticipated end date
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01/01/2007
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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450 patients
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Interventions
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Intervention: Computer algorithms are used to systematically transform data collected by an ongoing stroke register (SLSR) into individually tailored secondary prevention plans for patients, carers and the primary care team. The plans include details of the patient's current risk factor control and evidence based advice on how to improve risk factor management. Plans are updated and distributed at three time points.
Control: Usual care.
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Primary outcome measure(s)
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Prevalence of uncontrolled key modifiable risk factors for stroke (hypertension, smoking, aspirin adherence) measured at one year post stroke.
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Secondary outcome measure(s)
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Prevalence of other uncontrolled risk factors for stroke (cholesterol, diabetes, atrial fibrillation, obesity, heavy drinking); stroke recurrence rate.
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Sources of funding
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The Health Foundation 1824/1845,
The Stroke Association TSA G1,
Medical Research Council Special Training Fellowship Award G106/1105, Department of Health Career Scientist Award PHCSA02/07.
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Trial website
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Publications
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1. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20864664
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Contact name
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Prof
Charles
Wolfe
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Address
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Division of Health & Social Care Research
King's College London
7th Floor Capital House
42 Weston Street
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City/town
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London
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Zip/Postcode
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SE1 3QD
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Country
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United Kingdom
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Tel
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+44 (0)20 7848 6608
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Fax
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+44 2(0)0 7848 6620
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Email
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charles.wolfe@kcl.ac.uk
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Sponsor
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King's College London (UK)
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Address
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Division of Health and Social Care Research
7th Floor Capital House
42 Weston Street
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City/town
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London
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Zip/Postcode
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SE1 3QD
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Country
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United Kingdom
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Tel
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+44 (0)207848 6651/4113
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Fax
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+44 (0)207848 6620
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Email
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lesley.higgins@kcl.ac.uk
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Sponsor website:
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http://www.kcl.ac.uk
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Date applied
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19/07/2005
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Last edited
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07/12/2010
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Date ISRCTN assigned
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07/09/2005
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