Welcome
Support Centre
25 October 2014 
ISRCTN Register - International Standard Randomized Controlled Trial Number
Trial registration
Unique identification scheme
International databases
home  |   my details  |   ISRCTN Register  |   mRCT  |   links  |   information  |   news
Find trials
ISRCTN Register
tips on searching

Registration
New application
Updating record

Information
introduction
governing board
ISRCTN FAQs
data set
letter of agreement
request information
guidance notes
statistics

[ Print-friendly version ]
Stop Stroke: The South London Secondary Prevention Programme
ISRCTN ISRCTN10730637
DOI 10.1186/ISRCTN10730637
ClinicalTrials.gov identifier
EudraCT number
Public title Stop Stroke: The South London Secondary Prevention Programme
Scientific title
Acronym Stop Stroke
Serial number at source 1824/1845
Study hypothesis To test the efficacy of a complex secondary prevention intervention on improving post stroke risk factor control. The study uses a cluster randomised controlled trial design with 120 general practices randomised at the start of the trial. All participants at a given practice (patients, carers and primary care staff) receive either the intervention or usual care.
Lay summary
Ethics approval Not provided at time of registration.
Study design Randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Stroke
Participants - inclusion criteria All patients with a diagnosis of first-in-a-lifetime stroke living in Lambeth and Southwark.
Participants - exclusion criteria Patients must be alive six weeks post stroke, identified by the study team within six months of stroke and registered with a general practitioner.
Anticipated start date 21/07/2003
Anticipated end date 01/01/2007
Status of trial Completed
Patient information material
Target number of participants 450 patients
Interventions Intervention: Computer algorithms are used to systematically transform data collected by an ongoing stroke register (SLSR) into individually tailored secondary prevention plans for patients, carers and the primary care team. The plans include details of the patient's current risk factor control and evidence based advice on how to improve risk factor management. Plans are updated and distributed at three time points.
Control: Usual care.
Primary outcome measure(s) Prevalence of uncontrolled key modifiable risk factors for stroke (hypertension, smoking, aspirin adherence) measured at one year post stroke.
Secondary outcome measure(s) Prevalence of other uncontrolled risk factors for stroke (cholesterol, diabetes, atrial fibrillation, obesity, heavy drinking); stroke recurrence rate.
Sources of funding The Health Foundation 1824/1845,
The Stroke Association TSA G1,
Medical Research Council Special Training Fellowship Award G106/1105, Department of Health Career Scientist Award PHCSA02/07.
Trial website
Publications 1. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20864664
Contact name Prof  Charles  Wolfe
  Address Division of Health & Social Care Research
King's College London
7th Floor Capital House
42 Weston Street
  City/town London
  Zip/Postcode SE1 3QD
  Country United Kingdom
  Tel +44 (0)20 7848 6608
  Fax +44 2(0)0 7848 6620
  Email charles.wolfe@kcl.ac.uk
Sponsor King's College London (UK)
  Address Division of Health and Social Care Research
7th Floor Capital House
42 Weston Street
  City/town London
  Zip/Postcode SE1 3QD
  Country United Kingdom
  Tel +44 (0)207848 6651/4113
  Fax +44 (0)207848 6620
  Email lesley.higgins@kcl.ac.uk
  Sponsor website: http://www.kcl.ac.uk
Date applied 19/07/2005
Last edited 07/12/2010
Date ISRCTN assigned 07/09/2005
Submit your trial protocol
Submit to Trials journal
Follow us on Twitter
© 2014 ISRCTN unless otherwise stated.