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ISRCTN
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ISRCTN09311359
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ClinicalTrials.gov identifier
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Public title
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The contribution of race as a determining factor in the development of glaucoma
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Scientific title
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The contribution of race as a determining factor in the development of Primary Open Angle Glaucoma (POAG): An observational trial
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Acronym
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ADS (aqueous dynamic study)
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Serial number at source
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N/A
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Study hypothesis
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The distribution of aqueous production rate and the out-flow facility in patients from different racial groups with POAG.
Primary open angle glaucoma is defined as glaucomatous optic neuropathy together with an IOP >21 mmHg on at least one occasion and visual field defects (using the 24-2 test pattern on a Humphrey Field Analyzer) and a gonioscopic angle width of 3 or 4 and normal in appearance.
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Ethics approval
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St. Thomas' Hospital Research Ethics Committee, Approved on 14 August 2007, REC ref number: 07/Q0702/61
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Study design
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Prospective observational longitudinal non-randomised study
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Primary open angle glaucoma (POAG)
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Participants - inclusion criteria
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1. Males or Females between ages 18 and 90
2. Availability to participate in all aspects of the study
3. Willingness to participate in a study
4. Ability to undergo accurate fluorophotometry and tonography
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Participants - exclusion criteria
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1. History of intraocular surgery or keratorefractive surgery
2. Systemic medications which affects aqueous production, such as beta adrenergic blockers, steroids
3. Fluorescein allergy
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Anticipated start date
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15/10/2007
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Anticipated end date
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31/05/2010
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Status of trial
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Completed |
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Patient information material
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Not available in web format, please use contact details below to request a patient information sheet
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Target number of participants
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30 patients from each of the following race groups with or without POAG: African origin and White Caucasian
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Interventions
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Patients will receive standard treatment and care. Therefore, there is no intervention, just some extra measurements which used to be part of routine clinical examinations.
Additional measurements will be carried out using pnuematonometry, fluorophotometry and Schiotz tonography machines
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Primary outcome measure(s)
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Outflow facility determined
Comparison of results before and 3 months after treatment
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Secondary outcome measure(s)
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1. Anterior chamber depth
2. Intraocular pressure
Comparison of results before and 3 months after treatment
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Sources of funding
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Eye Hope Charity (UK)
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Trial website
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Publications
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Contact name
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Mr
Kin Sheng
Lim
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Address
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St. Thomas' Hospital
Westminster Bridge Road
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City/town
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London
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Zip/Postcode
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SE1 7EH
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Country
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United Kingdom
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Tel
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+44 (0)20 7188 2289
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Fax
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+44 (0)20 7188 4318
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Email
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shenglim@gmail.com
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Sponsor
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Guy's and St. Thomas NHS Foundation Trust (UK)
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Address
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c/o Karen Ignatian
Research and Development
3rd Floor Conybeare House
Guy's House
Guy's Hospital
St .Thomas Street
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City/town
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London
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Zip/Postcode
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SE1 9RT
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Country
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United Kingdom
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Tel
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+44 (0)20 7188 5731
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Fax
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+44 (0)20 7188 5434
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Email
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karen.ignatian@gstt.nhs.uk
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Sponsor website:
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http://www.guysandstthomas.nhs.uk/
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Date applied
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07/12/2009
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Last edited
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02/02/2010
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Date ISRCTN assigned
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02/02/2010
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