|
ISRCTN
|
ISRCTN06452574
|
|
ClinicalTrials.gov identifier
|
|
|
Public title
|
New therapeutic targets in stroke prevention: the effects of allopurinol on the cerebrovasculature of patients with subcortical stroke
|
|
Scientific title
|
|
|
Acronym
|
N/A
|
|
Serial number at source
|
N/A
|
|
Study hypothesis
|
Treatment with xanthine oxydase inhibitor allopurinol will improve cerebrovascular reactivity in patients with subcortical stroke.
|
|
Lay summary
|
|
|
Ethics approval
|
Not provided at time of registration
|
|
Study design
|
Randomised controlled trial
|
|
Countries of recruitment
|
United Kingdom
|
|
Disease/condition/study domain
|
Subcortical stroke.
|
|
Participants - inclusion criteria
|
1. Subcortical stroke
2. Index stroke within 2 weeks and 3 months prior to randomisation
|
|
Participants - exclusion criteria
|
1. >70% Internal carotid artery stenosis
2. Coronary artery disease
3. Other significant comorbidity
4. Contraindication to allopurinol
5. Contraindication to acetazolamide
6. Concurrent azathioprine or 6-mercaptopurine therapy
7. Serum creatinine >250 µmol/l
8. Woman of childbearing potential
|
|
Anticipated start date
|
01/11/2005
|
|
Anticipated end date
|
01/11/2007
|
|
Status of trial
|
Completed |
|
Patient information material
|
|
|
Target number of participants
|
80
|
|
Interventions
|
3 month allopurinol treatment (300 mg) versus lactose tablet.
|
|
Primary outcome measure(s)
|
The change in flow velocity in the middle cerebral artery (MCA) following acetazolomide infusion.
|
|
Secondary outcome measure(s)
|
1. Change in serum urate
2. Recurrent stroke or other cardiac event
|
|
Sources of funding
|
West Endowment Fund (UK)
|
|
Trial website
|
|
|
Publications
|
2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19916990
|
|
Contact name
|
Dr
Matthew
Walters
|
|
Address
|
Department of Medicine & Therapeutics
Western Infirmary
44 Church Street
|
|
City/town
|
Glasgow
|
|
Zip/Postcode
|
G11 6NT
|
|
Country
|
United Kingdom
|
|
Tel
|
+44 (0)141 211 2821
|
|
Fax
|
+44 (0)141 211 1863
|
|
Email
|
gcl203@clinmed.gla.ac.uk
|
|
Sponsor
|
Greater Glasgow NHS Board/Glasgow University (UK)
|
|
Address
|
c/o Judith Godden
Administration Building
Western Infirmary
Dumbarton Road
|
|
City/town
|
Glasgow
|
|
Zip/Postcode
|
G11 6NT
|
|
Country
|
United Kingdom
|
|
Tel
|
+44 (0)141 211 2000
|
|
Email
|
judith.godden@Northglasgow.NHS.Scot.UK
|
|
Date applied
|
09/09/2005
|
|
Last edited
|
01/02/2010
|
|
Date ISRCTN assigned
|
22/11/2005
|
