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Does targeted and quantified control of the microbiological environment within the ICU, using staff trained in microfibre cleaning and contamination bioload detection technology, reduce colonisation and healthcare-acquired infection?
ISRCTN ISRCTN06298448
DOI 10.1186/ISRCTN06298448
ClinicalTrials.gov identifier
EudraCT number
Public title Does targeted and quantified control of the microbiological environment within the ICU, using staff trained in microfibre cleaning and contamination bioload detection technology, reduce colonisation and healthcare-acquired infection?
Scientific title Microfibre cleaning and contamination bioload detection technology versus standard cleaning in a critical care unit to reduce local contamination rates: a prospective randomised controlled trial
Acronym N/A
Serial number at source 06/Q0502/91; UKCRN5751
Study hypothesis Use of microfibre in a supervised programme of cleaning and decontamination in a critical care unit reduces local contamination rates and new colonisation of patients with Methicillin-resistant Staphylococcus aureus (MRSA) and other hospital pathogens in comparison with standard cleaning.

As of 22/10/2009 details of an observational follow-up study have been added to this record. All details of this follow-up study can be found under the relevant field with the title: 'Follow-up study'.

Follow-up study:
A follow-up observational study was performed in which four different pathways of transmission were assessed in order to inform current Departmental policies for ward cleaning.
Lay summary
Ethics approval Joint UCL/UCLH Committee on the Ethics of Human Research approved on the 9th November 2006 (ref: 06/Q0502/91)
Study design Prospective randomised controlled cohort study
Countries of recruitment United Kingdom
Disease/condition/study domain Hospital-acquired infection
Participants - inclusion criteria All patients admitted to the critical care units of UCLH and Royal Free Hospitals. The critical care units are randomised to microfibre or standard cleaning. There is no patient intervention other than recording any infections developed.
Participants - exclusion criteria Does not meet inclusion criteria
Anticipated start date 02/04/2007
Anticipated end date 05/04/2008
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants 3 intensive care units, 14000 patient days, 4000 patients
Interventions A total environmental cleaning system based on microfibre and governed by standard operating procedures designed to achieve microbiological control of the entire near-patient environment.

Follow-up study:
This follow-up study will study intensively the bacterial reservoirs within a critical care and a general ward. In addition the movement of staff from one contact surface to another will be audited together with hand hygiene. Direct observation will be used but entirely anonymised. The project will also address spread of nosocomial pathogens in the environment by cleaning materials and airborne transmission.
Primary outcome measure(s) Proportion of the pooled results of all environmental swabs taken from bed areas on each day showing a target pathogen, e.g. MRSA
Secondary outcome measure(s) The rate of new acquisition by patients of MRSA and other target pathogens
Sources of funding National Institute for Health Research (NIHR) (UK) - HCAI Technology Innovation Programme (ref: 0140028)
Trial website
Publications 1. 2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21242793
Contact name Dr  Peter  Wilson
  Address Room 231 Windeyer Institute of Medical Sciences
University College London Hospitals
46 Cleveland Street
  City/town London
  Zip/Postcode W1T 4JF
  Country United Kingdom
  Tel +44 (0)207 380 9516
  Fax +44 (0)207 636 6482
  Email peter.wilson@uclh.nhs.uk
Sponsor National Institute for Health Research (NIHR) (UK)
  Address PO Box 407
  City/town Teddington
  Zip/Postcode TW11 0XX
  Country United Kingdom
  Tel +44 (0)20 8943 8990
  Fax +44 (0)20 8943 8972
  Email Joanne.Martin@nihr-ccf.org.uk
  Sponsor website: http://www.nihr-ccf.org.uk
Date applied 24/02/2007
Last edited 01/02/2011
Date ISRCTN assigned 21/03/2007
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