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Amsterdam Lifestyle Intervention on Food and Exercise at Work
ISRCTN ISRCTN04265725
DOI 10.1186/ISRCTN04265725
ClinicalTrials.gov identifier
EudraCT number
Public title Amsterdam Lifestyle Intervention on Food and Exercise at Work
Scientific title A randomised controlled trial on the preventive effects of a physical activity enhancing and healthy eating program on weight control among an overweight working population
Acronym ALIFE@Work
Serial number at source NTR43
Study hypothesis It is hypothesised that participation in a healthy lifestyle program, aimed at controlling body weight by increasing physical activity and improving eating habits, may contribute to the reduction of overweight, to weight maintenance and consequently to the prevention of health problems, like type two diabetes mellitus, hypertension, hypercholesterolaemia and cardiovascular diseases.
Lay summary Not provided at time of registration
Ethics approval The study design, procedures and informed consent form were approved by the Medical Ethics Committee of the VU University Medical Center (ref: 03/193), and all participants provided written informed consent.
Study design Randomised, active controlled, parallel group trial
Countries of recruitment Netherlands
Disease/condition/study domain Overweight
Participants - inclusion criteria 1. Paid employment on a permanent basis
2. Body Mass Index (BMI) greater than or equal to 25 kg/m^2
3. Adequate knowledge of the Dutch language
4. Access to the internet and knowledge of how to use it
5. At least 18 years of age
Participants - exclusion criteria Employees will be excluded for the following reasons:
1. Pregnancy
2. Diagnosis or treatment of cancer
3. Any other disorder that makes physical activity impossible
Anticipated start date 01/08/2002
Anticipated end date 01/08/2006
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants 1386
Interventions Block randomisation was used. In this randomised controlled trial, 1386 overweight employees are participating and being followed for two years. Participants are employees working at seven different companies throughout The Netherlands.

At baseline, employees were randomised to either one of two intervention conditions (phone-based [N = 462] or Internet-based intervention [N = 464]) or a reference group (N = 460). In addition, employees were randomised to either a group of employees having basic measures only (80% out of each group) or to a group of employees having additional measures (i.e. waist circumference, body fat percentage, blood pressure, total cholesterol level and fitness level; 20% subjects of each group). The two-step randomisation means there are six groups an employee could be assigned to.

Subjects in the phone-based group received the healthy lifestyle intervention program in a binder and were counselled by phone; subjects in the internet-based group followed the same program on the Internet and were counseled by e-mail. Subjects in the reference group received information brochures with general information on overweight, physical activity and healthy nutrition, and were not counselled. The intervention program lasted six months and took place in the first half year of the two years.
Primary outcome measure(s) 1. Change in body weight
2. Change in physical activity level
3. Change in dietary intake

Measurements are taken at baseline, and at 6, 12, 18 and 24 months of follow-up.
Secondary outcome measure(s) 1. Perceived health
2. Empowerment
3. Self-efficacy and stage-of-change in relation to weight control
4. Physical activity and eating habits
5. Sickness absence

Measurements are taken at baseline, and at 6, 12, 18 and 24 months of follow-up.
Sources of funding 1. Vrije University Medical Centre (VUMC) (The Netherlands) - EMGO-Institute
2. The Netherlands Heart Foundation (The Netherlands)
3. The Netherlands Organisation for Health Research and Development (ZonMw) (The Netherlands)
Trial website http://www.alifeatwork.nl
Publications 1. 2006 results in http://www.ncbi.nlm.nih.gov/pubmed/16723021
2. 2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21261935
3. 2012 economis evaluation in http://www.ncbi.nlm.nih.gov/pubmed/22967224
Contact name Dr  Caroline  Dekkers
  Address Van der Boechorststraat 7
  City/town Amsterdam
  Zip/Postcode 1081 BT
  Country Netherlands
  Tel +31 (0)20 444 1707
  Fax +31 (0)20 444 8387
  Email c.dekkers@vumc.nl
Sponsor Vrije University Medical Centre (VUMC) (The Netherlands)
  Address EMGO-Institute
Department of Public and Occupational Health
Van der Boechorststraat 7
  City/town Amsterdam
  Zip/Postcode 1081 BT
  Country Netherlands
  Sponsor website: http://www.vumc.nl/english/
Date applied 04/08/2005
Last edited 08/05/2013
Date ISRCTN assigned 04/08/2005
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