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Mastic Gum and Helicobacter Pylori eradication: an in vivo pilot study
ISRCTN ISRCTN01756929
DOI 10.1186/ISRCTN01756929
ClinicalTrials.gov identifier
EudraCT number
Public title Mastic Gum and Helicobacter Pylori eradication: an in vivo pilot study
Scientific title
Acronym MGHP
Serial number at source MGHP05
Study hypothesis Mastic gum is effective in eradicating Helicobacter pylori in vivo.
Lay summary
Ethics approval Ethics approval received from the Greek Medicines Agency Ethics Board on the 18th December 2005 (ref: MGCGH0032/06).
Study design Randomised controlled trial with three arms
Countries of recruitment Greece
Disease/condition/study domain Helicobacter pylori gastritis
Participants - inclusion criteria 1. Patients tested positive for H. pylori
2. Adults of either sex aged between 18 and 75 years of age
Participants - exclusion criteria 1. Pregnancy
2. Malignancy
3. Allergies to pantoprazole, amoxicillin, clarithromycin
Anticipated start date 01/12/2006
Anticipated end date 01/06/2007
Status of trial Completed
Patient information material
Target number of participants 42
Interventions Patients positive to Helicobacter pylori will be randomised to receive one of the following:

1. Mastic gum 2 g per day for 14 days
2. Mastic gum 2 g per day and pantoprazole 40 mg per day for 14 days
3. Pantoprazole 40 mg per day, amoxicillin 2 g per day and clarithromycin 1 g per day for 10 days

Follow up was two months after the end of the treatment for all study arms.
Primary outcome measure(s) Eradication of Helicobacter pylori, measured at five weeks after the end of treatment.
Secondary outcome measure(s) Helicobacter pylori load in patients remaining H. pylori positive, measured at five weeks after the end of treatment.
Sources of funding The Chios Mastic Gum Producers Cooperative (Greece)
Trial website
Publications 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/19879118
Contact name Dr  Konstantinos  Dabos
  Address Helenas Venizelou 2
  City/town Chios
  Zip/Postcode 821-00
  Country Greece
  Email kostasophia@yahoo.com
Sponsor The Chios Mastic Gum Producers Cooperative (Greece)
  Address Konstantinou Monomahou 1
  City/town Chios
  Zip/Postcode 821-00
  Country Greece
  Sponsor website: http://www.gummastic.gr
Date applied 31/03/2008
Last edited 20/09/2010
Date ISRCTN assigned 29/04/2008
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